Zebra Girl tells the story of three roommates (Sandra, Jack, and Crystal) whose lives are irrevocably transformed when they discover an ancient magical tome in their attic. When the book is slammed shut after an accidental demon-summoning, Sandra finds herself transformed into the eponymous Zebra Girl, a demon with black-and-white striped skin, hooves for feet, long, wicked talons, acidic bodily fluids, and the ability to set things on fire with her mind. Jack, blaming himself for the incident, devotes himself to the study of magic in hopes of finding a way to cure Sandra of her transformation, and along the way becomes a powerful archmage and the only hope of restoring magic to the world at large.