Like a contagious virus; pretty and athletic girls in their teens start disappearing around the globe one after another. The mastermind behind these abductions is Madame M; who plans to train these girls into professional killers. After several years of gruesome training; only Charlene; Katt and Jill survive and become the world's most sought after professional killers. On a recent mission to assassinate someone in Hong Kong; however CIA agent Jack; who vows to help her reclaim her past by eliminating Madame M.