Michelle Pfeiffer .... Melanie Parker
George Clooney .... Jack Taylor
Mae Whitman .... Maggie Taylor
Alex D. Linz .... Sammy Parker
Charles Durning .... Lew
Jon Robin Baitz .... Mr. Yates, Jr.
Ellen Greene .... Mrs. Elaine Lieberman
Joe Grifasi .... Manny Feldstein
Pete Hamill .... Frank Burroughs
Anna Maria Horsford .... Evelyn
Gregory Jbara .... Freddy
Sheila Kelley .... Kristen
Barry Kivel .... Mr. Yates, Sr.
Robert Klein .... Dr. Martin
George Martin .... Mr. Smith Leland
Michael Massee .... Eddie Parker
Amanda Peet .... Celia
Bitty Schram .... Marla
Holland Taylor .... Rita
Rachel York .... Liza
Marianne Muellerleile .... Ruta
Steven Jang .... Vincent Wang
Samantha Cintrón .... Rosa Lopez
Victor Truro .... Sammy's Pediatrician
Ashley Greenfield .... Jessica
Sidney Armus .... Mayor Sidney Aikens (as Sid Armus)
Hal Panchansky .... Metro Reporter
Maggie Wagner .... Daily News Reporter
Isabelle Ashland .... Daily News Reporter
Jasmin Hartmann .... Daily News Reporter
Larry Sherman .... Daily News Visitor
Duke Moosekian .... Foreign Artist Guy
Thomas Schall .... Gentleman
Michael Badalucco .... Lt. Bonomo
Jeanie Van Dam .... Old Woman
Kirstin Allen .... Pregnant Saleslady
Michael Genet .... Mayor Aikens' Press Secretary
Julia Ryder Perce .... Lew's Secretary
P.J. Aliseo .... Spiderman
Liam Ahern .... The Incredible Hulk
José Rabelo .... Museum Guard
Darla Hill .... Oribe's Receptionist
Joe Avellar .... Reporter
Jullie Chung .... Reporter
Dale Kasman .... Lady in the Police Station
Andrew Magarian .... Bum in the Police Station
Katherine Argo .... Passerby #1
Rob Kelly-Buntzen .... Passerby #2
Brian Cahill .... Passerby #3
Fred Goehner .... Davis
Kuniko Narai .... Flower Shop Employee
Susan Anbeh .... (uncredited)
Gideon Jacobs .... Billy (uncredited)
Harry Lavin .... Himself (uncredited)
Timothy Scott Ralston .... Architect (uncredited)

Melanie Parker, an architect and mother of Sammy, and Jack Taylor, a newspaper columnist and father of Maggie, are both divorced. They meet one morning when overwhelmed Jack is left unexpectedly with Maggie and forgets that Melanie was to take her to school. As a result, both children miss their school field trip and are stuck with the parents. The two adults project their negative stereotypes of ex-spouses on each other, but end up needing to rely on each other to watch the children as each must save his job. Humor is added by Sammy's propensity for lodging objects in his nose and Maggie's tendency to wander.

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